6 Jan
2023
6 Jan
'23
5:24 a.m.
Dear all,
I would like to ask if there is a way to measure the actual current that
is transmitted through the gap junction in NEST. With the example file
gap_junctions_two_neuron.py, I tried to use weight_recorder for the gap
junction, but only got a constant value of 0.5 (which is the "weight"
set in this file). It seems the "weight" here is only the conductance in
nS, after I quickly read the reference Hahne et al., 2015
<https://www.frontiersin.org/articles/10.3389/fninf.2015.00022/full>. Is
there a way in PyNEST to record the gap junction current? Thank you for
answering!
p.s. This is because I am developing astrocyte network models with NEST,
which uses a "sic_connection" (slow inward current connection) that is
adapted from gap_junction. I am trying to record its current in PyNEST
if possible. Unfortunately because the other collaborators developed the
sic_connection back then a while ago, I myself do not have an answer to
this. I will try other indirect methods, if there is no way to do such a
recording in PyNEST. If you have any relevant suggestions, please also
kindly let me know. Thanks again.
Happy new year,
Han-Jia
30 Jan
30 Jan
4:38 a.m.
Dear all,
In a discussion, Han-Jia and I concluded that it is not possible to
record the current mediated by a gap junction directly at the synapse.
Instead, we implemented a workaround. The postsynaptic neuron (a custom
neuron model implemented by Han-Jia) has an internal variable which
contains the sum of all incoming currents. By adding this variable to
the to the recordables list of the neuron model, it can be recorded
using a multimeter. This temporary solution was sufficient in this case,
as it was only needed for debugging purposes.
Best wishes,
Jonas
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participants (2)
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Hanjia Jiang -
Jonas Stapmanns